Effect of Mifepristone on Uterine Fibroid with special reference to Symptoms and its Size
Abstract
Uterine Fibroids are most common growth of female reproductive tract in premenopausal women. Non surgical treatment options for this have limitations. So this Prospective interventional study was conducted to evaluate the effect of low dose Mifepristone treatment for 3 months on fibroid size and related symptom.
Patients: Twenty five patients with symptomatic fibroid, aged 20-50 years.
Intervention: Patients received 10mg Mifepristone daily for 3 months
Method: Baseline data regarding fibroid volume, Hb value, PBAC (Pictorial Blood Assessment Chart) & VAS (Visual analogue Scheme) score were recorded and these data regarding above parametres again collected at the end of 1 st month & 3rd months of therapy.
Results: Mifepristone treatment significantly reduced fibroid mean volume from 91.13cm3 at enrollment to 38.73cm3 after 3months of treatment. Mean PBAC score was reduced for 111.52 at enrollment to 2.36 at the end of 3rd month of therapy. At 3 months 22 of 25 case (88%) developed amenorrhoea. At the end of therapy hemoglobin mean value was raised by 2.38 gm/dL from the baseline mean value of 8.70mg./dL. There were no major side effects during the course of the study and treatment was well tolerated. Conclusion: Low dose Mifepristone (10mg) reduces fibroid size and related symptoms with no side effects among women with symptomatic fibroids.
Keywords
Download Options
Introduction
Uterine leiomyoma are commonest benign gynaecological tumours occurring in up to 25 percent of women in reproductive age and about 40 percent have symptoms severe enough to warrant therapy1 , with peak incidence of symptoms occurring in women in their 30s and 40s. Uterine fibroids are most common growth of female reproductive tract, 2-3 times more common in Afro-Carribbean women. Definitive treatment for symptomatic myomas has always been surgical and myomas accounts for 40 percent of all hysterectomies in premenopausal women2 . Non surgical treatment options for symptomatic myomas have limitations.
Conclusion
Low dose Mifepristone showed a speedy & better control of bleeding and alleviation of pain related symptoms that improved general condition of women, relieved their anxiety, provided them a sense of well being with few ignorable side effects.
Mifepristone can be used for temporary relief of symptoms for short periods. This application is suitable in women with symptomatic fibroids in perimenopausal years or in patients not suitable for surgery due to medical reasons.